Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

EP Hedges; H Dickson; S Tognin; G Modinos; M Antoniades; M van der Gaag; L de Haan; P McGorry; C Pantelis; A Riecher-Rössler; R Bressan; N Barrantes-Vidal; MO Krebs; M Nordentoft; S Ruhrmann; G Sachs; BP Rutten; J van Os; LR Valmaggia; P McGuire; MJ Kempton

Journal article

Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

EP Hedges, H Dickson, S Tognin, G Modinos, M Antoniades, M van der Gaag, L de Haan, P McGorry, C Pantelis, A Riecher-Rössler, R Bressan, N Barrantes-Vidal, MO Krebs, M Nordentoft, S Ruhrmann, G Sachs, BP Rutten, J van Os, LR Valmaggia, P McGuire Show all

Schizophrenia Research Cognition | Published : 2022

DOI: 10.1016/j.scog.2021.100222

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Abstract

Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on antipsychotic medication, and 60 healthy contro..

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University of Melbourne Researchers

Patrick McGorry Author

Christos Pantelis Author

Lucia Valmaggia Author

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Grants

Awarded by Seventh Framework Programme

Funding Acknowledgements

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community's Seventh Framework Programme. Additional support was provided by a Medical Research Council Fellowship to M Kempton (grant MR/J008915/1) and by the Ministerio de Ciencia, Innovacion e Universidades (PSI2017-87512-C2-1-R) and the Generalitat de Catalunya (2017SGR1612) to N Barrantes-Vidal. C Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825), a NHMRC Program Grant (ID:1150083).